Iohexol Injection

Iohexol Injection is a non-ionic Contrast Media. Compared with a traditional ionic Contrast Media, Iohexol Injection has an excellent molecular structure and it can greatly improve user safety and significantly reduce adverse reactions. The iodinated contrast agent has excellent clinical feedback and good imaging results. In 1998, Iohexol Injection was launched as Beilu’s 1st iodinated Contrast Media.

Precautions of Iohexol Injection

General precautions for the use of nonionic-monomer contrast agent:

1. Special attention should be paid to patients with allergies, asthma and adverse reactions to iodinated contrast agents. Prophylactic medications such as steroids and H1/H2 histamine receptor antagonists may be considered for these patients.

2. The risk of serious reactions related to this type of CT contrast agent is low. However, iodinated contrast agents can provoke anaphylactoid reactions or other allergic reactions. Therefore, first aid measures should be trained in advance, and necessary rescue drugs and devices should be prepared for possible serious reactions.

3. In view of the low accuracy of pre-test in predicting allergic reactions caused by nonionic contrast agents and the possibility that the pre-test itself may lead to serious allergic reactions, it is not recommended to use pretest to predict iodine allergic reactions.

4. Venous access should be kept smooth throughout the X-ray examination.

5. In the in-vitro tests, the effect of nonionic contrast agents on the coagulation system is lighter than that of ionic contrast agents. During angiography, great care should be taken in the intravascular technical procedures, and the catheter should be irrigated with heparinized saline from time to time to reduce the thrombosis and embolism related to the technical procedures.

6. Patients, especially patients with multiple myeloma, diabetes, renal insufficiency, infants and young children, and the elderly, must be appropriately hydrated before and after the use of contrast agent. Electrolyte disturbance and hemodynamic disorders are common in infants (< 1 year old), particularly neonates. Special attention should be paid to patients with serious heart diseases and pulmonary arterial hypertension because they are prone to developing hemodynamic disorders and cardiac rhythm disturbances.

7. Patients with acute encephalopathy, brain tumour or history of epilepsy should be prevented from seizures, and special attention should be paid to them. The risks of seizures and neurologic reactions are significantly increased in patients with alcohol or drug abuse. Transient hearing loss or deafness occurs in a few patients after myelography, which is possibly caused by a decrease in CSF pressure after lumbar puncture.

8. In view of the high risks of acute renal failure after the use of contrast agent, special attention should be paid to patients with pre-existing renal impairment and diabetes and patients with atypical globulinemia (multiple myelomatoses and Waldenstrom macroglobulinemia).

9. Preventive actions include:

10. Observation time:

Patients should be observed for at least 30 minutes after the use of the contrast agent because most serious adverse reactions occur during this period. However, there is still the possibility of a delayed response.

11. Intraspinal injection:

After myelography, patients should rest for 1 h with 20°-raised head and chest. Patients can carefully get out of bed and walk without bending over. If patients are still in bed, keep their head and chest raised for 6 hours. Patients with low seizure thresholds should be closely monitored during this period, and outpatients should not stay alone for the first 24 hours.

12. Effects on the ability to drive vehicles and operate machines:

Do not drive a vehicle or operate a machine within 24 hours after intraspinal injection.

13. As with all non-gastrointestinal drugs, this product should be visually inspected before use to check for particulate matter, discoloration and container damage.

This type of Iohexol contrast agent should be drawn into the barrel before use. Each vial is for single use only, and the unused portion should be discarded.

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